Ferguson taught Argentinian Tango at a dance company in Sweden for a few years. In 2013, Rebecca played Queen Elizabeth Woodville in the BBC historical drama The White Queen (2013), for which she got a Golden Globe nomination.
In 2015, Ferguson played Ilsa Faust, the female lead in Mission: Impossible – Rogue Nation (2015). Her co-star, Tom Cruise, chose her for the film after having seen her in the mini-series The White Queen (2013). Her performance in the movie was highly praised and Rebecca will reprise her role in the sixth Mission: Impossible film.
In 2016, she starred in Despite the Falling Snow (2016), Florence Foster Jenkins (2016) and The Girl on the Train (2016). Her upcoming projects are Life (2017), The Snowman (2017), The Greatest Showman (2017), The Lady and the Panda and Mission: Impossible – Fallout (2018).